For an oocyte to be ready for fertilization and expansion into an embryo, the ideal list of genes needs to be turned on. Namekawa suspected this pre-programming from the oocyte genome happens in various stages — the primary one particular setting up throughout the time a feminine is born. He believed that chromatin remodeling proteins did A great deal of this do the job, by shifting spools all-around.
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This protein may perhaps “create and maintain the chromatin state,” here claims Namekawa — keeping the spools in place plus the oocytes genetically primed given that the mouse matures.
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